Certainly, you can paint over plasterboard without skimming. Before painting, however, it’s essential to ensure the plasterboard is properly prepared. Start by applying a primer or sealer to the board, which helps the paint adhere better and provides a more uniform finish. Once the primer is dry, you can proceed with your chosen paint. Do note that while this method is quicker than skimming, the final appearance might highlight imperfections or joint lines more than a skimmed surface would.